Jakes mice: Searching for answers to the puzzle of autism – Associated Press

Im Jake,” the 16-year-old stated, naming the little furry creature crafted to have the very same genetic problem he has.That mouse and its lab-grown family members are the very first in the world to mirror the missing gene that triggers Jakes autism. Scientists at Washington University in St. Louis reproduced the mice, and grew stem cells derived from Jakes blood, to study and discover methods to treat his rare disorder– and look for responses to the larger puzzle of autism.Jakes family raised cash for the early research, which scientists then parlayed into a $4 million grant from the National Institutes of Health to dig more deeply into Jakes gene, one of more than 100 implicated in autism.”JAKES GIFTThe Litvags understood early on that Jake wasnt reaching childhood turning points.

Im Jake,” the 16-year-old stated, calling the little furry animal engineered to have the same hereditary problem he has.That mouse and its lab-grown relatives are the very first in the world to mirror the missing gene that triggers Jakes autism. Scientists at Washington University in St. Louis bred the mice, and grew stem cells obtained from Jakes blood, to study and discover ways to treat his rare condition– and look for responses to the larger puzzle of autism.Jakes family raised money for the early research study, which researchers then parlayed into a $4 million grant from the National Institutes of Health to dive more deeply into Jakes gene, one of more than 100 linked in autism.”JAKES GIFTThe Litvags understood early on that Jake wasnt reaching childhood milestones. “Its simply that individuals are born all the time” with hereditary differences.The couple, whose more youthful child Jordan does not have the condition, talked openly with Jake about his autism and attempted to bolster his self-esteem when he stressed about being seen as various. They recently released about the mice in the journal Neuron.While researchers cant go back and see how Jakes brain established, Dougherty said, mice enable them to see the mutation play out through generations.A GIFT IN RETURNDougherty and his associates hope what they find out about how MYT1L works eventually leads to medicines or gene therapies that enhance or even remedy the problems the mutation causes.