The Spike protein on the surface area of SARS-CoV-2 virus (significant in red) acknowledges the hACE2 protein (marked in blue) that protrudes from healthy human cells in the throat and lungs. In this method, the Spike protein acts like a secret that enables the virus to invade the cell and use its machinery to recreate itself. The recently established RNA aptamer (marked in yellow) binds the Spike protein very strongly and blocks it ability to acknowledge ACE2, therefore avoiding more infection.
Hence, the RNA aptamer is not a new type of vaccine however a compound that can possibly stop the virus from spreading in the body once somebody is exposed to the infection.
The effective binding to SARS-CoV-2 infection also indicates that the aptamer can be used to check for covid-19 infection.
” We have started testing the new aptamer in fast tests and we anticipate to be able to find very low concentrations of the virus,” states Professor Jørgen Kjems from Aarhus University who is the primary author of the article which has actually simply been released in the prominent journal, PNAS.
Research studies in cell culture reveal that the aptamer works versus the previous variants of coronavirus that the scientists had the opportunity to test.
” Since we sent the post for peer evaluation, we have actually continued our research studies and been able to reveal that it likewise recognizes the delta variant. Now we are waiting for samples of the recently identified variant, omicron, so we can test whether the aptamer likewise recognizes that,” states Jørgen Kjems.
He highlights, that the results with the delta version have not yet been peer evaluated and released.
Reference: “A serum-stable RNA aptamer particular for SARS-CoV-2 neutralizes viral entry” by Julián Valero, Laia Civit, Daniel M. Dupont, Denis Selnihhin, Line S. Reinert, Manja Idorn, Brett A. Israels, Aleksandra M. Bednarz, Claus Bus, Benedikt Asbach, David Peterhoff, Finn S. Pedersen, Victoria Birkedal, Ralf Wagner, Søren R. Paludan and Jørgen Kjems, 7 December 2021, Proceedings of the National Academy of Sciences.DOI: 10.1073/ pnas.2112942118.
Funding: Carlsberg Foundation, Danish National Research Foundation, EU Horizon2020.
The Spike protein on the surface area of SARS-CoV-2 infection (significant in red) recognizes the hACE2 protein (significant in blue) that extends from healthy human cells in the throat and lungs. In this way, the Spike protein acts like a secret that allows the infection to invade the cell and use its machinery to replicate itself.
A research team at Aarhus University has actually developed a new molecule that connects to the surface area of SARS-CoV-2 infection particles. This accessory avoids the infection from getting in human cells and spreading out the infection.
The recently developed molecule belongs to a class of compounds known as RNA aptamers and it is based upon the exact same kind of foundation that are utilized for mRNA vaccines. This makes them much cheaper and easier to produce than the antibodies that are presently used to deal with Covid-19 and to discover viral infection utilizing fast antigen tests.
An aptamer is a piece of DNA or RNA that folds into a 3D structure that can recognize a particular target molecule of interest. By attaching itself to the virus surface, the RNA aptamer prevents the Spike protein from functioning as a secret that allows the virus to go into a cell.