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Johns Hopkins scientists examining weird side effects of COVID-19 suggest one way coronavirus ‘gains a foothold in the body’ – MarketWatch

https://www.marketwatch.com/story/johns-hopkins-scientists-examining-weird-side-effects-of-covid-19-say-this-could-be-how-virus-gains-a-foothold-in-the-body-2020-08-19

In a research study released in the European Respiratory Journal on Wednesday, the researchers discovered extremely high levels of “angiotensin transforming enzyme II,” or ACE-2, just in the area of the nose responsible for smelling. The ACE-2 enzyme is believed to be the entrance that enables coronavirus to go into the cells of the body and trigger an infection.

Its an odd adverse effects. But could it provide ideas regarding how coronavirus attacks the body?
Why do some individuals with COVID-19 lose their sense of odor? And what can be learned from that? Researchers studying tissue got rid of from clients noses during surgery think they may have discovered the reason that so numerous individuals with COVID-19 lose their sense of smell, even when they have no other symptoms and, as an outcome, one method the infection gets in the body.


These outcomes recommend that this location of the nose might be where the coronavirus is getting entry to the body.

— Dr. Mengfei Chen, a research study associate at Johns Hopkins School of Medicine

Scientists at the Johns Hopkins University School of Medicine in Baltimore carried out the research study, led by Professor Andrew Lane, director of the department of rhinology and skull base surgery, and Dr. Mengfei Chen, a research study partner. They used fluorescent dyes on the tissue samples to identify and picture the existence of ACE-2 in the nose cells.

” The olfactory epithelium is quite a simple part of the body for an infection to reach, its not buried away deep in our body, and the really high levels of ACE-2 that we found there might describe why its so simple to capture COVID-19,” Chen said. Lane added that this research study may make it possible for doctors to tackle the infection with antiviral therapies provided straight through the nose.

” This technique allowed us to see that the levels of ACE-2– the COVID-19 entry point protein were greatest in the part of the nose that allows us to smell,” Chen said. “These outcomes suggest that this location of the nose could be where the coronavirus is gaining entry to the body.” They found the most ACE-2 on the lining cells of the “olfactory epithelium” at the back of the nose where we detect smells.

The study used these samples from the back of the nose of 23 clients, gotten rid of throughout endoscopic surgeries for conditions such as tumors or “persistent rhinosinusitis,” an inflammatory disease of the nose and sinus. They likewise studied biopsies from the trachea (windpipe) of 7 clients. None of the clients had actually been detected with coronavirus.

In fact, the levels of ACE-2 in these cells was between 200 and 700 times higher than other tissue in the nose and trachea, Chen said, and they found likewise high levels in all the samples of olfactory epithelium. The ACE-2 enzyme was not identified on olfactory neurons, the afferent neuron that pass details about smells to the brain.

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It could also be one factor why COVID-19 is so transmittable and, he added, this theory might possibly use more effective treatments. “It suggests that the part of our nose responsible for smelling might also be the place where the coronavirus gets a grip in the body. This finding will need to be validated, but it provides possible new opportunities for treating the infection.”


Another study discovered evidence of direct viral damage to the olfactory system in 2 clients who passed away from COVID-19.

Numerous typical respiratory infections, such as colds and coughs, can make us briefly lose our sense of smell, said Tobias Welte, teacher of lung medicine and director of the Department of Pulmonary and Infectious Diseases at Hannover University School of Medicine, Germany. Welte, who was not included in this study, said this research study may expose why that happens in so many patients.

Since Wednesday, the U.S. still had the worlds highest number of COVID-19 cases (5,486,232) and deaths (171,877). Worldwide, there had been 22,179,934 verified cases and 781,932 deaths. COVID-19 attacks the respiratory system, however physicians say it likewise affects the cardiovascular system, causing and impacting organs embolism amongst some patients, even young ones.

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in combination with Oxford University; BioNTech SE.
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and partner Pfizer.
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; GlaxoSmithKline.
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Johnson & & Johnson.
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; Merck & & Co
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; Moderna.
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; and Sanofi.
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are amongst those are currently pursuing COVID-19 vaccines.

Why do some individuals with COVID-19 lose their sense of odor? Scientists studying tissue got rid of from patients noses during surgical treatment think they might have discovered the factor why so numerous individuals with COVID-19 lose their sense of odor, even when they have no other symptoms and, as a result, one way the infection gets in the body.

A separate study launched earlier this month and published in JAMA Otolaryngology– Head & & Neck Surgery, a peer-reviewed journal, took a look at the nasal cells of two clients who had actually passed away of SARS-CoV-2, the virus that causes the disease COVID-19, and discovered proof of direct viral damage to the sensory system used for smelling in patients checking favorable for SARS-CoV-2.

The research study used these samples from the back of the nose of 23 patients, removed throughout endoscopic surgical treatments for conditions such as growths or “persistent rhinosinusitis,” an inflammatory illness of the nose and sinus.” This method allowed us to see that the levels of ACE-2– the COVID-19 entry point protein were greatest in the part of the nose that allows us to smell,” Chen said. COVID-19 attacks the respiratory system, but physicians state it likewise affects the cardiovascular system, causing and impacting organs blood clots amongst some clients, even young ones.

Some more youthful COVID-19 clients who were otherwise healthy are suffering loss of taste and/or smell, blood clots and strokes. Many “long-haulers”– COVID-19 clients who have actually continued showing signs for months after the preliminary infection passed– report neurological problems including confusion, problem focusing, headaches, extreme fatigue, state of mind modifications and insomnia.

Coronavirus update: The Dow Jones Industrial Index
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the S&P 500.
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and the Nasdaq Composite.
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were trading greater on Wednesday in the middle of hope for Round 2 of Congresss pandemic relief program. The S&P 500 index notched its very first record close given that Feb. 19 on Tuesday, according to Dow Jones Market Data.